Chapter 25



1. Mell LK, Malik R, Komaki R, Movsas B, Swann RS, Langer C, Antonadou D, Koukourakis M, Mundt AJ. Effect of amifostine on response rates in locally advanced non-small-cell lung cancer patients treated on randomized controlled trials: a meta-analysis. Int J Radiat Oncol Biol Phys. 2007 May 1;68(1):111-8.


Sasse AD, Clark LG, Sasse EC, Clark OA.  Amifostine reduces side effects and improves complete response rate during radiotherapy: results of a meta-analysis. Int J Radiat Oncol Biol Phys. 2006 Mar 1;64(3):784-91.


2. Ohguri T, Imada H, Kohshi K, Kakeda S, Ohnari N, Morioka T, Nakano K, Konda N, Korogi Y. Effect of prophylactic hyperbaric oxygen treatment for radiation-induced brain injury after stereotactic radiosurgery of brain metastases. Int J Radiat Oncol Biol Phys. 2007 Jan 1;67(1):248-55.


Lynn M, Friedman WA. Hyperbaric oxygen in the treatment of a radiosurgical complication: technical case report. Neurosurgery. 2007 Mar;60(3):E579.


Kohshi K, Yamamoto H, Nakahara A, Katoh T, Takagi M. Fractionated stereotactic radiotherapy using gamma unit after hyperbaric oxygenation on recurrent high-grade gliomas. J Neurooncol. 2007 May;82(3):297-303.


Al-Waili NS, Butler GJ, Beale J, Hamilton RW, Lee BY, Lucas P. Hyperbaric oxygen and malignancies: a potential role in radiotherapy, chemotherapy, tumor surgery and phototherapy. Med Sci Monit. 2005 Sep;11(9):RA279-89.


3. Kim SH, Weil RJ, Chao ST, Toms SA, Angelov L, Vogelbaum MA, Suh JH, Barnett GH. Stereotactic radiosurgical treatment of brain metastases in older patients. Cancer. 2008 Jun 5. [Epub ahead of print]


Goetsch SJ. Linear accelerator and gamma knife-based stereotactic cranial radiosurgery: challenges and successes of existing quality assurance guidelines and paradigms. Int J Radiat Oncol Biol Phys. 2008;71(1 Suppl):S118-21.


Ewend MG, Morris DE, Carey LA, Ladha AM, Brem S. Guidelines for the initial management of metastatic brain tumors: role of surgery, radiosurgery, and radiation therapy. J Natl Compr Canc Netw. 2008 May;6(5):505-13.


4. Penka I, Kaplan Z, Sefr R, Sirotek L, Eber Z, Ondrák M. Use of radiofrequency ablation in the treatment of malignant liver lesions. Hepatogastroenterology. 2008 Mar-Apr;55(82-83):562-7.


Jakobs TF, Hoffmann RT, Schrader A, Stemmler HJ, Trumm C, Lubienski A, Murthy R, Helmberger TK, Reiser MF. CT-Guided Radiofrequency Ablation in Patients with Hepatic Metastases from Breast Cancer. Cardiovasc Intervent Radiol. 2008 Jun 25. [Epub ahead of print]


Lencioni R, Crocetti L, Cioni R, Suh R, Glenn D, Regge D, Helmberger T, Gillams AR, Frilling A, Ambrogi M, Bartolozzi C, Mussi A. Response to radiofrequency ablation of pulmonary tumours: a prospective, intention-to-treat, multicentre clinical trial (the RAPTURE study). Lancet Oncol. 2008 Jul;9(7):621-8.


Hiraki T, Mimura H, Gobara H, Sano Y, Fujiwara H, Date H, Kanazawa S. Repeat radiofrequency ablation for local progression of lung tumors: does it have a role in local tumor control? J Vasc Interv Radiol. 2008 May;19(5):706-11.


5. Keall P, Vedam S, George R, Bartee C, Siebers J, Lerma F, Weiss E, Chung T. The clinical implementation of respiratory-gated intensity-modulated radiotherapy. Med Dosim. 2006 Summer;31(2):152-62.


Mageras GS, Yorke E. Deep inspiration breath hold and respiratory gating strategies for reducing organ motion in radiation treatment. Semin Radiat Oncol. 2004 Jan;14(1):65-75.



6. Cahlon O, Hunt M, Zelefsky MJ. Intensity-modulated radiation therapy: supportive data for prostate cancer. Semin Radiat Oncol. 2008 Jan;18(1):48-57.


Hatano K, Araki H, Sakai M, Kodama T, Tohyama N, Kawachi T, Imazeki M, Shimizu T, Iwase T, Shinozuka M, Ishigaki H. Current status of intensity-modulated radiation therapy (IMRT). Int J Clin Oncol. 2007 Dec;12(6):408-15.


Nguyen PL, Zietman AL. High-dose external beam radiation for localized prostate cancer: current status and future challenges. Cancer J. 2007 Sep-Oct;13(5):295-301.


Seung S, Bae J, Solhjem M, Bader S, Gannett D, Hansen EK, Louie J, Underhill K, Cha C. Intensity-Modulated Radiotherapy for Head-and-Neck Cancer in the Community Setting. Int J Radiat Oncol Biol Phys. 2008 May 15. [Epub ahead of print]


Popovtzer A, Eisbruch A. Advances in radiation therapy of head and neck cancer. Expert Rev Anticancer Ther. 2008 Apr;8(4):633-44.


7. Laramore GE, Krall JM, Griffin TW, Duncan W, Richter MP, Saroja KR, Maor MH, Davis LW. Neutron versus photon irradiation for unresectable salivary gland tumors: final report of an RTOG-MRC randomized clinical trial. Radiation Therapy Oncology Group. Medical Research Council. Int J Radiat Oncol Biol Phys. 1993 Sep 30;27(2):235-40.


Laramore GE, Krall JM, Thomas FJ, Russell KJ, Maor MH, Hendrickson FR, Martz KL, Griffin TW, Davis LW. Fast neutron radiotherapy for locally advanced prostate cancer. Final report of Radiation Therapy Oncology Group randomized clinical trial. Am J Clin Oncol. 1993 Apr;16(2):164-7.


Douglas JG, Goodkin R, Laramore GE. Gamma knife stereotactic radiosurgery for salivary gland neoplasms with base of skull invasion following neutron radiotherapy.

Head Neck. 2008 Apr;30(4):492-6.


Douglas JG, Koh WJ, Austin-Seymour M, Laramore GE. Treatment of salivary gland neoplasms with fast neutron radiotherapy. Arch Otolaryngol Head Neck Surg. 2003 Sep;129(9):944-8.


8. Chan AW, Liebsch NJ. Proton radiation therapy for head and neck cancer. J Surg Oncol. 2008 Jun 15;97(8):697-700.


Pommier P, Liebsch NJ, Deschler DG, Lin DT, McIntyre JF, Barker FG 2nd, Adams JA, Lopes VV, Varvares M, Loeffler JS, Chan AW. Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg. 2006 Nov;132(11):1242-9.


9. Bergs JW, Franken NA, Haveman J, Geijsen ED, Crezee J, van Bree C.

Hyperthermia, cisplatin and radiation trimodality treatment: a promising cancer treatment? A review from preclinical studies to clinical application. Int J Hyperthermia. 2007 Jun;23(4):329-41.


Helm CW, Randall-Whitis L, Martin RS 3rd, Metzinger DS, Gordinier ME, Parker LP, Edwards RP. Hyperthermic intraperitoneal chemotherapy in conjunction with surgery for the treatment of recurrent ovarian carcinoma. Gynecol Oncol. 2007 Apr;105(1):90-6.


Issels RD. Regional hyperthermia in high-risk soft tissue sarcomas. Curr Opin Oncol. 2008 Jul;20(4):438-43.


Hildebrandt B, Hegewisch-Becker S, Kerner T, Nierhaus A, Bakhshandeh-Bath A, Janni W, Zumschlinge R, Sommer H, Riess H, Wust P; The German Interdisciplinary Working Group on Hyperthermia. Current status of radiant whole-body hyperthermia at temperatures >41.5 degrees C and practical guidelines for the treatment of adults. The German 'Interdisciplinary Working Group on Hyperthermia'. Int J Hyperthermia. 2005 Mar;21(2):169-83.


Sanki A, Kam PC, Thompson JF. Long-term results of hyperthermic, isolated limb perfusion for melanoma: a reflection of tumor biology. Ann Surg. 2007 Apr;245(4):591-6.


10. Bairati I, Meyer F, Gélinas M, Fortin A, Nabid A, Brochet F, Mercier JP, Têtu B, Harel F, Mâsse B, Vigneault E, Vass S, del Vecchio P, Roy J. A randomized trial of antioxidant vitamins to prevent second primary cancers in head and neck cancer patients. J Natl Cancer Inst. 2005 Apr 6;97(7):481-8.


Meyer F, Bairati I, Jobin E, Gélinas M, Fortin A, Nabid A, Têtu B. Acute adverse effects of radiation therapy and local recurrence in relation to dietary and plasma beta carotene and alpha tocopherol in head and neck cancer patients. Nutr Cancer. 2007;59(1):29-35.


Bairati I, Meyer F, Jobin E, Gélinas M, Fortin A, Nabid A, Brochet F, Têtu B. Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients. Int J Cancer. 2006 Nov 1;119(9):2221-4.


Meyer F, Bairati I, Fortin A, Gélinas M, Nabid A, Brochet F, Têtu B. Interaction between antioxidant vitamin supplementation and cigarette smoking during radiation therapy in relation to long-term effects on recurrence and mortality: a randomized trial among head and neck cancer patients. Int J Cancer. 2008 Apr 1;122(7):1679-83.


11. Cerchietti LC, Navigante AH, Lutteral MA, Castro MA, Kirchuk R, Bonomi M, Cabalar ME, Roth B, Negretti G, Sheinker B, Uchima P.  Double-blinded, placebo-controlled trial on intravenous L-alanyl-L-glutamine in the incidence of oral mucositis following chemoradiotherapy in patients with head-and-neck cancer.  Int J Radiat Oncol Biol Phys. 2006 Aug 1;65(5):1330-7.


Erbil Y, Oztezcan S, Giris M, Barbaros U, Olgac V, Bilge H, Kucucuk H, Toker G.

The effect of glutamine on radiation-induced organ damage.  Life Sci. 2005 Dec 12;78(4):376-82.


Kozelsky TF, Meyers GE, Sloan JA, Shanahan TG, Dick SJ, Moore RL, Engeler GP, Frank AR, McKone TK, Urias RE, Pilepich MV, Novotny PJ, Martenson JA; North Central Cancer Treatment Group. Phase III double-blind study of glutamine versus placebo for the prevention of acute diarrhea in patients receiving pelvic radiation therapy. J Clin Oncol. 2003 May 1;21(9):1669-74.


Wang WS, Lin JK, Lin TC, Chen WS, Jiang JK, Wang HS, Chiou TJ, Liu JH, Yen CC, Chen PM. Oral glutamine is effective for preventing oxaliplatin-induced neuropathy in colorectal cancer patients. Oncologist. 2007 Mar;12(3):312-9.


Yoshida S, Matsui M, Shirouzu Y, Fujita H, Yamana H, Shirouzu K. Effects of glutamine supplements and radiochemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer. Ann Surg. 1998 Apr;227(4):485-91.


12. Zhang Li-ying, et al. Clinical observations on San Shen Tang (Three Sengs Decoction) in oncological radiation therapy. Shi Yong Zhong Yi Nei Ke Za Zhi (Journal of Practical Chinese Medical Internal Medicine). 2006; 1: 53-54.


Cai HB, Dai FG, Min QF, Shi M, Miao JX, Luo RC.  [Clinical study of the effects of radiotherapy in combination with traditional Chinese medicine on non-small cell lung cancer]. Di Yi Jun Yi Da Xue Xue Bao. 2002 Dec;22(12):1112-3.


Cai HB, Luo RC. [Prevention and therapy of radiation-induced pulmonary injury with traditional Chinese medicine] Di Yi Jun Yi Da Xue Xue Bao. 2003 Sep;23(9):958-60.


13. McLaughlin N, Annabi B, Bouzeghrane M, Temme A, Bahary JP, Moumdjian R, Beliveau R. The Survivin-mediated radioresistant phenotype of glioblastomas is regulated by RhoA and inhibited by the green tea polyphenol (-)-epigallocatechin-3-gallate. Brain Res. 2006 Feb 3;1071(1):1-9.


Baatout S, Derradji H, Jacquet P, Mergeay M.  Increased radiation sensitivity of an eosinophilic cell line following treatment with epigallocatechin-gallate, resveratrol and curcuma. Int J Mol Med. 2005 Feb;15(2):337-52.


Yamamoto T, Staples J, Wataha J, Lewis J, Lockwood P, Schoenlein P, Rao S, Osaki T, Dickinson D, Kamatani T, Schuster G, Hsu S.  Protective effects of EGCG on salivary gland cells treated with gamma-radiation or cis-platinum(II)diammine dichloride. Anticancer Res. 2004 Sep-Oct;24(5A):3065-73.


Yamamoto T, Hsu S, Lewis J, Wataha J, Dickinson D, Singh B, Bollag WB, Lockwood P, Ueta E, Osaki T, Schuster G.  Green tea polyphenol causes differential oxidative environments in tumor versus normal epithelial cells. J Pharmacol Exp Ther. 2003 Oct;307(1):230-6.


14. Wang Y, Raffoul JJ, Che M, Doerge DR, Joiner MC, Kucuk O, Sarkar FH, Hillman GG.  Prostate cancer treatment is enhanced by genistein in vitro and in vivo in a syngeneic orthotopic tumor model. Radiat Res. 2006 Jul;166(1 Pt 1):73-80.


Raffoul JJ, Wang Y, Kucuk O, Forman JD, Sarkar FH, Hillman GG.  Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest. BMC Cancer. 2006 Apr 26;6:107.


Piva R, Belardo G, Santoro MG.  NF-kappaB: a stress-regulated switch for cell survival. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):478-86.


Kim BY, Kim KA, Kwon O, Kim SO, Kim MS, Kim BS, Oh WK, Kim GD, Jung M, Ahn JS.  NF-kappaB inhibition radiosensitizes Ki-Ras-transformed cells to ionizing radiation. Carcinogenesis. 2005 Aug;26(8):1395-403.


15. Ortmann EK, Mayerhofer T, Getoff N, Kodym R.  Effect of antioxidant vitamins on radiation-induced apoptosis in cells of a human lymphoblastic cell line. Radiat Res. 2004 Jan;161(1):48-55.


16. Colas S, Paon L, Denis F, Prat M, Louisot P, Hoinard C, Le Floch O, Ogilvie G, Bougnoux P.  Enhanced radiosensitivity of rat autochthonous mammary tumors by dietary docosahexaenoic acid. Int J Cancer. 2004 Apr 10;109(3):449-54.


Minami Y, Miyata H, Doki Y, Yano M, Yamasaki M, Takiguchi S, Fujiwara Y, Yasuda T, Monden M. [omega-3 Fatty acid-containing diet (Racol) reduces toxicity of chemoradiation therapy for patients with esophageal cancer] Gan To Kagaku Ryoho. 2008 Mar;35(3):437-40.


17. Kupin VI, Polevaia EB. [Stimulation of the immunological reactivity of cancer patients by Eleutherococcus extract] Vopr Onkol. 1986;32(7):21-6.


18. Ha SW, Yi CJ, Cho CK, Cho MJ, Shin KH, Park CI.  Enhancement of radiation effect by Ginkgo biloba extract in C3H mouse fibrosarcoma. Radiother Oncol. 1996 Nov;41(2):163-7.


Chen HS, Zhai F, Chu YF, Xu F, Xu AH, Jia LC. [Clinical study on treatment of patients with upper digestive tract malignant tumors of middle and late stage with Ginkgo biloba exocarp polysaccharides capsule preparation] Zhong Xi Yi Jie He Xue Bao. 2003 Sep;1(3):189-91.


19. Zimmerer T, Böcker U, Wenz F, Singer MV. Medical prevention and treatment of acute and chronic radiation induced enteritis--is there any proven therapy? a short review.

Z Gastroenterol. 2008 May;46(5):441-8.


Delia P, Sansotta G, Donato V, Messina G, Frosina P, Pergolizzi S, De Renzis C.

Prophylaxis of diarrhoea in patients submitted to radiotherapeutic treatment on pelvic district: personal experience. Dig Liver Dis. 2002 Sep;34 Suppl 2:S84-6.


Demirer S, Aydintug S, Aslim B, Kepenekci I, Sengül N, Evirgen O, Gerceker D, Andrieu MN, Ulusoy C, Karahüseyinoglu S. Effects of probiotics on radiation-induced intestinal injury in rats. Nutrition. 2006 Feb;22(2):179-86.


Seal M, Naito Y, Barreto R, Lorenzetti A, Safran P, Marotta F. Experimental radiotherapy-induced enteritis: a probiotic interventional study. J Dig Dis. 2007 Aug;8(3):143-7.


Ried K. Gastrointestinal health. The role of pro- and pre-biotics in standard foods. Aust Fam Physician. 2004 Apr;33(4):253-5.


Beyzadeoğlu M, Balkan M, Demiriz M, Tibet H, Dirican B, Oner K, Pak Y. Protective effect of vitamin A on acute radiation injury in the small intestine. Radiat Med. 1997 Jan-Feb;15(1):1-5.


Levitsky J, Hong JJ, Jani AB, Ehrenpreis ED. Oral vitamin a therapy for a patient with a severely symptomatic postradiation anal ulceration: report of a case. Dis Colon Rectum. 2003 May;46(5):679-82.


Mutlu-Türkoğlu U, Erbil Y, Oztezcan S, Olgaç V, Toker G, Uysal M. The effect of selenium and/or vitamin E treatments on radiation-induced intestinal injury in rats. Life Sci. 2000 Apr 7;66(20):1905-13.


de Moraes Ramos FM, Schönlau F, Novaes PD, Manzi FR, Bóscolo FN, de Almeida SM. Pycnogenol protects against Ionizing radiation as shown in the intestinal mucosa of rats exposed to X-rays. Phytother Res. 2006 Aug;20(8):676-9.


Erbil Y, Oztezcan S, Giriş M, Barbaros U, Olgaç V, Bilge H, Küçücük H, Toker G.

The effect of glutamine on radiation-induced organ damage. Life Sci. 2005 Dec 12;78(4):376-82.


Anderson PM, Schroeder G, Skubitz KM. Oral glutamine reduces the duration and severity of stomatitis after cytotoxic cancer chemotherapy. Cancer. 1998 Oct 1;83(7):1433-9.


Wu GH, Zhang YW, Wu ZH. Modulation of postoperative immune and inflammatory response by immune-enhancing enteral diet in gastrointestinal cancer patients. World J Gastroenterol. 2001 Jun;7(3):357-62.


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20. Pommier P, Gomez F, Sunyach MP, D'Hombres A, Carrie C, Montbarbon X.

Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J Clin Oncol. 2004 Apr 15;22(8):1447-53.


Merchant TE, Bosley C, Smith J, Baratti P, Pritchard D, Davis T, Li C, Xiong X. A phase III trial comparing an anionic phospholipid-based cream and aloe vera-based gel in the prevention of radiation dermatitis in pediatric patients. Radiat Oncol. 2007 Dec 19;2:45.


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21. Anderson PM, Schroeder G, Skubitz KM. Oral glutamine reduces the duration and severity of stomatitis after cytotoxic cancer chemotherapy. Cancer. 1998 Oct 1;83(7):1433-9.


Hirasawa M, Takada K. Multiple effects of green tea catechin on the antifungal activity of antimycotics against Candida albicans. J Antimicrob Chemother. 2004 Feb;53(2):225-9.


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