Chapter 18

References

 

1. Boros LG. Lee WN. Go VL. A metabolic hypothesis of cell growth and death in pancreatic cancer.  Pancreas. 24(1):26-33, 2002

 

Gatenby RA. Potential role of FDG-PET imaging in understanding tumor-host interaction. Journal of Nuclear Medicine. 1995; 36(5):893-9

 

Planas M. Porta I. Padro JB. Carbohydrate and lipid metabolism in the cancer.  Nutricion Hospitalaria. 9(2):69-77, 1994

 

Fischer CP.  Bode BP.  Souba WW. Adaptive alterations in cellular metabolism with malignant transformation. Annals of Surgery.  227(5):627-34, 1998

 

Mathupala SP.  Rempel A.  Pedersen PL.  Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase.  Journal of Bioenergetics & Biomembranes.  29(4):339-43, 1997

 

2. Boyd DB.  Insulin and cancer. Integr Cancer Ther. 2003; 2(4):315-29

 

Ioannou GN, Splan MF, Weiss NS, McDonald GB, Beretta L, Lee SP. Incidence and predictors of hepatocellular carcinoma in patients with cirrhosis. Clin Gastroenterol Hepatol. 2007 Aug;5(8):938-45, 945.e1-4.

 

Lai MS, Hsieh MS, Chiu YH, Chen TH. Type 2 diabetes and hepatocellular carcinoma: A cohort study in high prevalence area of hepatitis virus infection. Hepatology. 2006 Jun;43(6):1295-302

 

Balkau B, Barrett-Connor E, Eschwege E, Richard JL, Claude JR, Ducimetiere P.  Diabetes and pancreatic carcinoma.  Diabete Metab. 1993; 19(5):458-62.

 

Meyerhardt JA, Catalano PJ, Haller DG, Mayer RJ, Macdonald JS, Benson AB 3rd, Fuchs CS. Impact of diabetes mellitus on outcomes in patients with colon cancer. J Clin Oncol. 2003 Feb 1;21(3):433-40.

 

3. Goodwin PJ, Enniks M, Pritchard KI, Trudeau ME, Koo J, Madarnas Y, Hartwick W, Hoffman B, Hood N.  Fasting insulin and outcome in early-stage breast cancer:  results of a prospective cohort study.  J Clin Oncol 2002 20(1):42-51.

 

Hammarsten J, Högstedt B. Hyperinsulinaemia: a prospective risk factor for lethal clinical prostate cancer. Eur J Cancer. 2005 Dec;41(18):2887-95

 

4. Santisteban GA. Ely JT. Hamel EE. Read DH. Kozawa SM. Glycemic modulation of tumor tolerance in a mouse model of breast cancer. Biochemical & Biophysical Research Communications. 132(3):1174-9, 1985

 

5. Mathupala SP.  Rempel A.  Pedersen PL.  Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase.  Journal of Bioenergetics & Biomembranes.  29(4):339-43, 1997

 

Igarashi M. Wakasaki H. Takahara N. Ishii H. Jiang ZY. Yamauchi T. Kuboki K. Meier M. Rhodes CJ. King GL. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. Journal of Clinical Investigation. 103(2):185-95, 1999

 

Yerneni KK. Bai W. Khan BV. Medford RM. Natarajan R. Hyperglycemia-induced activation of nuclear transcription factor kappaB in vascular smooth muscle cells. Diabetes. 48(4):855-64, 1999

 

Deora AA. Win T. Vanhaesebroeck B. Lander HM. A redox-triggered ras-effector interaction. Recruitment of phosphatidylinositol 3'-kinase to Ras by redox stress. Journal of Biological Chemistry. 273(45):29923-8, 1998

 

6. Gapstur SM. Gann PH. Colangelo LA. Barron-Simpson R. Kopp P. Dyer A. Liu K. Postload plasma glucose concentration and 27-year prostate cancer mortality (United States). Cancer Causes & Control. 12(8):763-72, 2001

 

7. Siddiqui AA, Spechler SJ, Huerta S, Dredar S, Little BB, Cryer B. Elevated HbA1c Is an Independent Predictor of Aggressive Clinical Behavior in Patients with Colorectal Cancer: A Case-Control Study. Dig Dis Sci. 2008 Apr 12. [Epub ahead of print]

 

8. Yee D.  The insulin-like growth factor system as a treatment target in breast cancer.  Seminars in Oncology. 29(3 Suppl 11):86-95, 2002

 

Oh JS. Kucab JE. Bushel PR. Martin K. Bennett L. Collins J. DiAugustine RP. Barrett JC. Afshari CA. Dunn SE.  Insulin-like growth factor-1 inscribes a gene expression profile for angiogenic factors and cancer progression in breast epithelial cells.  Neoplasia (New York). 4(3):204-17, 2002

 

Lee AV. Cui X. Oesterreich S.  Cross-talk among estrogen receptor, epidermal growth factor, and insulin-like growth factor signaling in breast cancer.  Clinical Cancer Research. 7(12 Suppl):4429s-4435s, 2001

 

Zhang X, Yee D.  Tyrosine kinase signalling in breast cancer: insulin-like growth factors and their receptors in breast cancer. Breast Cancer Research. 2(3):170-5, 2000

 

9. Furstenberger G. Senn HJ. Insulin-like growth factors and cancer. Lancet Oncology. 2002; 3(5):298-302.

 

Boyd DB. Insulin and cancer. Integr Cancer Ther. 2003 Dec;2(4):315-29.

 

Tang HB, Ren YP, Zhang J, Ma SH, Gao F, Wu YP. [Correlation of insulin-like growth factor-1 (IGF-1) to angiogenesis of breast cancer in IGF-1-deficient mice] Ai Zheng. 2007 Nov;26(11):1215-20.

 

Gennigens C, Menetrier-Caux C, Droz JP. Insulin-Like Growth Factor (IGF) family and prostate cancer. Crit Rev Oncol Hematol. 2006 May;58(2):124-45.

 

Scotlandi K, Picci P. Targeting insulin-like growth factor 1 receptor in sarcomas. Curr Opin Oncol. 2008 Jul;20(4):419-27.

 

10. Moschos SJ, Mantzoros CS.  The role of the IGF system in cancer: from basic to clinical studies and clinical applications. Oncology. 2002;63(4):317-32

 

Lu Y, Zi X, Zhao Y, Mascarenhas D, Pollak M.  Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst. 2001;93(24):1852-7.

 

Beech DJ, Parekh N, Pang Y.  Insulin-like growth factor-I receptor antagonism results in increased cytotoxicity of breast cancer cells to doxorubicin and taxol. Oncol Rep. 2001 Mar-Apr;8(2):325-9.

 

Singer CF, Hudelist G, Schreiber M, Kubista E. Pharmacological modulation of IGF serum concentrations as a therapeutic approach to control the growth of malignant breast tumors. Drugs Today (Barc). 2003 Feb;39(2):115-25.

 

11. Singer CF, Hudelist G, Schreiber M, Kubista E. Pharmacological modulation of IGF serum concentrations as a therapeutic approach to control the growth of malignant breast tumors. Drugs Today (Barc). 2003 Feb;39(2):115-25.

 

Lee AV, Weng CN, Jackson JG, Yee D. Activation of estrogen receptor-mediated gene transcription by IGF-I in human breast cancer cells. J Endocrinol. 1997 Jan;152(1):39-47.

 

12. Lu Y, Zi X, Zhao Y, Mascarenhas D, Pollak M.  Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst. 2001;93(24):1852-7.

 

Dieras V, Vincent-Salomon A, Degeorges A, Beuzeboc P, Mignot L, de Cremoux P.

[Trastuzumab (Herceptin) and breast cancer: mechanisms of resistance] Bull Cancer. 2007 Mar 1;94(3):259-66.

 

13. Lorenz RA, Lorenz RM, Codd JE. Perioperative blood glucose control during adult coronary artery bypass surgery. AORN J. 2005 Jan;81(1):126-44, 147-50.

 

Hernandez CM.  Surgery and diabetes.  Minimizing the risks.  Am J Nurs. 1987; 87(6):788-92.

 

Togo S, Matsuo K, Tanaka K, Matsumoto C, Shimizu T, Ueda M, Morioka D, Nagano Y, Endo I, Shimada H. Perioperative infection control and its effectiveness in hepatectomy patients. J Gastroenterol Hepatol. 2007 Nov;22(11):1942-8.

 

14. Gennari A, Salvadori B, Donati S, Bengala C, Orlandini C, Danesi R, Del Tacca M, Bruzzi P, Conte PF. Cardiotoxicity of epirubicin/paclitaxel-containing regimens: role of cardiac risk factors. J Clin Oncol. 1999 Nov;17(11):3596-602.

 

15. Westover AN, Marangell LB.  A cross-national relationship between sugar consumpton and major depression?  Depress Anxiety 2002; 16:118-20.

 

Winokur A, Maislin G, Phillips JL, Amsterdam JD.  Insulin resistance after oral glucose tolerance testing in patients with major depression.  Am J Psychiatry 1988; 145:325-30.

 

Nathan RS, Sachar EJ, Asnis GM, Halbreich U, Halpern FS.  Relative insulin insensitivity and cortisol secretion in depressed patients.  Psychiatry Res 1981; 4:291-300.

 

Weber B, Schweiger U, Deuschle M, Heuser I.  Major depression and impaired glucose tolerance.  Exp Clin Endocrinol Diabetes. 2000;108(3):187-90.

 

Okamura F, Tashiro A, Utumi A, Imai T, Suchi T, Tamura D, Sato Y, Suzuki S, Hongo M.  Insulin resistance in patients with depression and its changes during the clinical course of depression: minimal model analysis.  Metabolism. 2000 Oct;49(10):1255-60.

 

16. Ramasubbu R.  Insulin resistance:  a metabolic link between depressive disorder and atherosclerotic vascular diseases.  Med Hypotheses 2002; 59:537-51.

 

Salazar MR. Alpha lipoic acid:  a novel treatment for depression.  Med Hypotheses 2000; 55:510-2.

 

Singer CF, Hudelist G, Schreiber M, Kubista E. Pharmacological modulation of IGF serum concentrations as a therapeutic approach to control the growth of malignant breast tumors. Drugs Today (Barc). 2003 Feb;39(2):115-25.

 

Lee AV, Weng CN, Jackson JG, Yee D. Activation of estrogen receptor-mediated gene transcription by IGF-I in human breast cancer cells. J Endocrinol. 1997 Jan;152(1):39-47.

 

17. Lelbach A, Muzes G, Feher J. Current perspectives of catabolic mediators of cancer cachexia. Med Sci Monit. 2007 Sep;13(9):RA168-173.

 

18. Jenkins DJ.  Josse RG.  Jenkins AL.  Wolever TM.  Vuksan V. Implications of altering the rate of carbohydrate absorption from the gastrointestinal tract.  Clinical & Investigative Medicine - Medecine Clinique et Experimentale.  18(4):296-302, 1995

 

Colditz GA, Willett WC, Rotnitzky A, Manson JE. Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med 1995;122:481-6

 

Bryhni B, Jenssen TG, Olafsen K, Eikrem JH. Age or waist as determinant of insulin action? Metabolism. 2003 Jul;52(7):850-7.

 

Pereira MA, Kartashov AK, van Horn L, Slattery M, Jacobs DR, Ludwig DS.  Reported breakfast habits and incidence of obesity and the insulin resistance syndrome in young black and white adults:  the CARDIA study.  Circulation 2003; 107: 16, abstract P35.

 

Croezen S, Visscher TL, Ter Bogt NC, Veling ML, Haveman-Nies A. Skipping breakfast, alcohol consumption and physical inactivity as risk factors for overweight and obesity in adolescents: results of the E-MOVO project. Eur J Clin Nutr. 2007 Nov 28. [Epub ahead of print].

 

19. Gangwisch JE, Heymsfield SB, Boden-Albala B, Buijs RM, Kreier F, Pickering TG, Rundle AG, Zammit GK, Malaspina D. Sleep duration as a risk factor for diabetes incidence in a large U.S. sample. Sleep. 2007 Dec 1;30(12):1667-73.

 

20. Vgontzas AN, Zoumakis E, Bixler EO, Lin HM, Follett H, Kales A, Chrousos GP. Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. J Clin Endocrinol Metab. 2004 May;89(5):2119-26.

 

21. Raikkonen K.  Keltikangas-Jarvinen L.  Adlercreutz H. Hautanen A. Psychosocial stress and the insulin resistance syndrome. Metabolism: Clinical & Experimental.  45(12):1533-8, 1996

 

Mooy JM, de Vries H, Grootenhuis PA, Bouter LM, Heine RJ. Major stressful life events in relation to prevalence of undetected type 2 diabetes: the Hoorn Study. Diabetes Care. 2000 Feb;23(2):197-201.

 

Kyrou I, Chrousos GP, Tsigos C. Stress, visceral obesity, and metabolic complications. Ann N Y Acad Sci. 2006 Nov;1083:77-110.

 

22. Yang X, Telama R, Hirvensalo M, Mattsson N, Viikari JS, Raitakari OT. The Longitudinal Effects of Physical Activity History on Metabolic Syndrome. Med Sci Sports Exerc. 2008 Jul 8. [Epub ahead of print]

 

 LeRoith D. Dyslipidemia and glucose dysregulation in overweight and obese patients. Clin Cornerstone. 2007;8(3):38-52.

 

23. Riccardi G. Rivellese AA.  Dietary treatment of the metabolic syndrome--the optimal diet. British Journal of Nutrition. 2000;83 Suppl 1:S143-8

 

Anderson JW.  Dietary fibre, complex carbohydrate and coronary artery disease. Canadian Journal of Cardiology. 1995;11 Suppl G:55G-62G

 

Fukagawa NK. Anderson JW. Hageman G. Young VR. Minaker KL.  High-carbohydrate, high-fiber diets increase peripheral insulin sensitivity in healthy young and old adults.  American Journal of Clinical Nutrition. 1990;52(3):524-8

 

Lovejoy J. DiGirolamo M.  Habitual dietary intake and insulin sensitivity in lean and obese adults. American Journal of Clinical Nutrition. 1992;55(6):1174-9

 

Frost G.  Keogh B.  Smith D.  Akinsanya K.  Leeds A. The effect of low-glycemic carbohydrate on insulin and glucose response in vivo and in vitro in patients with coronary heart disease.  Metabolism: Clinical & Experimental. 1996;45(6):669-72.

 

McKeown NM, Meigs JB, Liu S, Saltzman E, Wilson PW, Jacques PF. Carbohydrate nutrition, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham Offspring Cohort. Diabetes Care. 2004 Feb;27(2):538-46.

 

24. Saris WH. Sugars, energy metabolism, and body weight control. Am J Clin Nutr. 2003 Oct;78(4):850S-857S.

 

Liu S, Willett WC, Manson JE, Hu FB, Rosner B, Colditz G. Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women. Am J Clin Nutr. 2003; 78(5):920-7.

 

Wright DW, Hansen RI, Mondon CE, Reaven GM. Sucrose-induced insulin resistance in the rat: modulation by exercise and diet. Am J Clin Nutr 1983;38:879–83.

 

Reiser S, Hallfrisch J, Fields M, et al. Effects of sugars on indices of glucose tolerance in humans. Am J Clin Nutr 1986;43:151–9.

 

25. Lee JS, Pinnamaneni SK, Eo SJ, Cho IH, Pyo JH, Kim CK, Sinclair AJ, Febbraio MA, Watt MJ. Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular  accumulation of lipid metabolites. J Appl Physiol. 2006 May;100(5):1467-74. 

 

Vessby B.  Dietary fat and insulin action in humans.  Br J Nutr 2000; 83 Suppl 1:S91-6.

 

Boeing H, Weisgerber UM, Jeckel A, Rose H-J, Kroke A.  Association between glycated hemoglobin and diet and other lifestyle factors in a nondiabetic population:  cross-sectional evaluation fo data from the Potsdam cohort of the European Prospective Investigation into Cancer and Nutrition Study.  Am J Clin Nutr 2000; 71:1115-22.

 

O'Dea K.  Westernization and non-insulin-dependent diabetes in Australian Aborigines. Ethnicity & Disease. 1991;1(2):171-87

 

Barnard RJ. Roberts CK. Varon SM. Berger JJ.  Diet-induced insulin resistance precedes other aspects of the metabolic syndrome.  Journal of Applied Physiology. 1998;84(4):1311-5

 

Chen M.  Bergman RN.  Porte D Jr. Insulin resistance and beta-cell dysfunction in aging: the importance of dietary carbohydrate.  Journal of Clinical Endocrinology & Metabolism. 1988;67(5):951-7

 

Barnard RJ. Youngren JF. Martin DA.  Diet, not aging, causes skeletal muscle insulin resistance.  Gerontology. 1995;41(4):205-11

 

Kaklamani VG.  Linos A.  Kaklamani E.  Markaki I. Koumantaki Y.  Mantzoros CS. Dietary fat and carbohydrates are independently associated with circulating insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 concentrations in healthy adults. Journal of Clinical Oncology. 1999;17(10):3291-8

 

Kari FW. Dunn SE. French JE. Barrett JC.  Roles for insulin-like growth factor-1 in mediating the anti-carcinogenic effects of caloric restriction.  Journal of Nutrition, Health & Aging. 1999;3(2):92-101

 

Zeyda M, Stulnig TM. Adipose tissue macrophages. Immunol Lett. 2007 Oct 15;112(2):61-7.

 

26. Yam D, Eliraz A, Berry EM. Diet and disease--the Israeli paradox: possible dangers of a high omega-6 polyunsaturated fatty acid diet.  Isr J Med Sci. 1996 Nov;32(11):1134-43.

 

Rasic-Milutinovic Z, Perunicic G, Pljesa S, Gluvic Z, Sobajic S, Djuric I, Ristic D. Effects of N-3 PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients. Ren Fail. 2007;29(3):321-9.

 

Haugaard SB, Madsbad S, Høy CE, Vaag A. Dietary intervention increases n-3 long-chain polyunsaturated fatty acids in skeletal muscle membrane phospholipids of obese subjects. Implications for insulin sensitivity.

Clin Endocrinol (Oxf). 2006 Feb;64(2):169-78.

 

27. Due A, Larsen TM, Hermansen K, Stender S, Holst JJ, Toubro S, Martinussen T, Astrup A. Comparison of the effects on insulin resistance and glucose tolerance of 6-mo high-monounsaturated-fat, low-fat, and control diets. Am J Clin Nutr. 2008 Apr;87(4):855-62.

 

Riccardi G. Rivellese AA.  Dietary treatment of the metabolic syndrome--the optimal diet. British Journal of Nutrition. 2000;83 Suppl 1:S143-8.

 

28. Anon.  Culinary herbs.  Available at: http://www.vegetarian-nutrition.info/vn/herb-spice.php.  Accessed July 12, 2008.

 

29. Rozen F. Pollak M.  Inhibition of insulin-like growth factor I receptor signaling by the vitamin D analogue EB1089 in MCF-7 breast cancer cells: A role for insulin-like growth factor binding proteins.  International Journal of Oncology. 15(3):589-94, 1999

 

Nickerson T. Huynh H.  Vitamin D analogue EB1089-induced prostate regression is associated with increased gene expression of insulin-like growth factor binding proteins.  Journal of Endocrinology. 160(2):223-9, 1999

 

Oh YS. Kim EJ. Schaffer BS. Kang YH. Binderup L. MacDonald RG. Park JH. Synthetic low-calcaemic vitamin D(3) analogues inhibit secretion of insulin-like growth factor II and stimulate production of insulin-like growth factor-binding protein-6 in conjunction with growth suppression of HT-29 colon cancer cells. Molecular & Cellular Endocrinology. 183(1-2):141-9, 2001

 

Singer CF, Hudelist G, Schreiber M, Kubista E.  Pharmacological modulation of IGF serum concentrations as a therapeutic approach to control the growth of malignant breast tumors. Drugs Today (Barc). 2003; 39(2):115-25

 

Marchesini G. Bugianesi E. Ronchi M. Flamia R. Thomaseth K. Pacini G. Zinc supplementation improves glucose disposal in patients with cirrhosis. Metabolism: Clinical & Experimental. 47(7):792-8, 1998

 

Brun JF. Guintrand-Hugret R. Fons C. Carvajal J. Fedou C. Fussellier M. Bardet L. Orsetti A.  Effects of oral zinc gluconate on glucose effectiveness and insulin sensitivity in humans. Biological Trace Element Research. 47(1-3):385-91, 1995

 

Bierhaus A. Chevion S. Chevion M. Hofmann M. Quehenberger P. Illmer T. Luther T. Berentshtein E. Tritschler H. Muller M. Wahl P. Ziegler R. Nawroth PP.  Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells.  Diabetes. 46(9):1481-90, 1997

 

Suzuki YJ. Tsuchiya M. Packer L. Lipoate prevents glucose-induced protein modifications.  Free Radical Research Communications. 17(3):211-7, 1992.

 

30. Anderson RA. Chromium and polyphenols from cinnamon improve insulin sensitivity. Proc Nutr Soc. 2008 Feb;67(1):48-53.

 

Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003 Dec;26(12):3215-8.

 

Verspohl EJ, Bauer K, Neddermann E. Antidiabetic effect of Cinnamomum cassia and Cinnamomum zeylanicum In vivo and In vitro. Phytotherapy Research. 2005 June 2;19(3):203-206.

31. Panagiotakos DB, Lionis C, Zeimbekis A, Makri K, Bountziouka V, Economou M, Vlachou I, Micheli M, Tsakountakis N, Metallinos G, Polychronopoulos E. Long-term, moderate coffee consumption is associated with lower prevalence of diabetes mellitus among elderly non-tea drinkers from the Mediterranean Islands (MEDIS Study). Rev Diabet Stud. 2007 Summer;4(2):105-11.

Hemmerle H, Burger HJ, Below P, et al. Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase. J Med Chem. 1997 Jan 17;40(2):137-45.

Sudano I, Binggeli C, Spieker L, et al. Cardiovascular effects of coffee: is it a risk factor? Prog Cardiovasc Nurs. 2005 Spring;20(2):65-9.

Cheng JT, Liu IM. Stimulatory effect of caffeic acid on alpha1A-adrenoceptors to increase glucose uptake into cultured C2C12 cells. Naunyn Schmiedeberg’s Arch Pharmacol. 2000 Aug;362(2):122-7.

Yukawa GS, Mune M, Otani H, et al. Effects of coffee consumption on oxidative susceptibility of low-density lipoproteins and serum lipid levels in humans. Biochemistry (Mosc). 2004 Jan;69(1):70-4.

Abidoff MT. Special clinical report on effects of glucose-6-phosphatase on human subjects. Russian Ministry of Health, Moscow, 1999. Unpublished study.

Johnston KL, Clifford MN, Morgan LM. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. Am J Clin Nutr. 2003 Oct;78(4):728-33.

Cheng JT, Liu IM. Stimulatory effect of caffeic acid on alpha1A-adrenoceptors to increase glucose uptake into cultured C2C12 cells. Naunyn Schmiedeberg’s Arch Pharmacol. 2000 Aug;362(2):122-7.

van Dam RM, Feskens EJM. Coffee consumption and risk of type 2 diabetes mellitus. Lancet. 2002 Nov 9;360(9344):1477-8.

32. Ni Yanxia, et al., Therapeutic effect of berberine on 60 patients with non-insulin dependent diabetes mellitus and experimental research, Chinese Journal of Integrated Traditional and Western Medicine 1995; 1(2); 91-95.

 

33. Gupta P, Yadav DK, Siripurapu KB, Palit G, Maurya R. Constituents of Ocimum sanctum with antistress activity. J Nat Prod. 2007 Sep;70(9):1410-6.

 

Narendhirakannan RT, Subramanian S, Kandaswamy M. Biochemical evaluation of antidiabetogenic properties of some commonly used Indian plants on streptozotocin-induced diabetes in experimental rats. Clin Exp Pharmacol Physiol. 2006 Dec;33(12):1150-7.

 

34. Walfisch S, Walfisch Y, Kirilov E, Linde N, Mnitentag H, Agbaria R, Sharoni Y, Levy J. Tomato lycopene extract supplementation decreases insulin-like growth factor-I levels in colon cancer patients. Eur J Cancer Prev. 2007 Aug;16(4):298-303.

 

35. Singer CF, Hudelist G, Schreiber M, Kubista E.  Pharmacological modulation of IGF serum concentrations as a therapeutic approach to control the growth of malignant breast tumors. Drugs Today (Barc). 2003; 39(2):115-25.

 

36. Rozen F. Pollak M.  Inhibition of insulin-like growth factor I receptor signaling by the vitamin D analogue EB1089 in MCF-7 breast cancer cells: A role for insulin-like growth factor binding proteins.  International Journal of Oncology. 15(3):589-94, 1999

 

Nickerson T. Huynh H.  Vitamin D analogue EB1089-induced prostate regression is associated with increased gene expression of insulin-like growth factor binding proteins.  Journal of Endocrinology. 160(2):223-9, 1999

 

Oh YS. Kim EJ. Schaffer BS. Kang YH. Binderup L. MacDonald RG. Park JH. Synthetic low-calcaemic vitamin D(3) analogues inhibit secretion of insulin-like growth factor II and stimulate production of insulin-like growth factor-binding protein-6 in conjunction with growth suppression of HT-29 colon cancer cells. Molecular & Cellular Endocrinology. 183(1-2):141-9, 2001.

 

Forouhi NG, Luan J, Cooper A, Boucher BJ, Wareham NJ. Baseline serum 25-hydroxy vitamin D is predictive of future glycaemic status and insulin resistance: The MRC Ely prospective study 1990 - 2000. Diabetes. 2008; 57(10):2619-25.

 

37. Anon. Cinnamon linked to oral sores, irritation. J Am Dent Assoc. 1995 Sep;126(9):1214.

 

38. Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care. 2003 Apr;26(4):1277-94.

 

Vuksan V, Sievenpiper JL, Koo VY, Francis T, Beljan-Zdravkovic U, Xu Z, Vidgen E. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med. 2000 Apr 10;160(7):1009-13.

 

39. Krawinkel MB, Keding GB. Bitter gourd (Momordica Charantia): A dietary approach to hyperglycemia. Nutr Rev. 2006 Jul;64(7 Pt 1):331-7.

 

Yin J, Zhang H, Ye J. Traditional chinese medicine in treatment of metabolic syndrome. Endocr Metab Immune Disord Drug Targets. 2008 Jun;8(2):99-111.

40. Anderson RA.  Chromium, glucose intolerance and diabetes.  Journal of the American College of Nutrition. 17(6):548-55, 1998

 

Bahijri SM.  Effect of chromium supplementation on glucose tolerance and lipid profile. Saudi Medical Journal. 21(1):45-50, 2000.

 

Mertz W.  Chromium research from a distance: from 1959 to 1980. Journal of the American College of Nutrition. 17(6):544-7, 1998.

 

Anderson RA. Chromium and polyphenols from cinnamon improve insulin sensitivity. Proc Nutr Soc. 2008 Feb;67(1):48-53.

 

Wang ZQ, Qin J, Martin J, Zhang XH, Sereda O, Anderson RA, Pinsonat P, Cefalu WT. Phenotype of subjects with type 2 diabetes mellitus may determine clinical response to chromium supplementation. Metabolism. 2007 Dec;56(12):1652-5.

 

41. Ramel A, Martinéz A, Kiely M, Morais G, Bandarra NM, Thorsdottir I. Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults. Diabetologia. 2008 Jul;51(7):1261-8.

 

Tsitouras PD, Gucciardo F, Salbe AD, Heward C, Harman SM. High omega-3 fat intake improves insulin sensitivity and reduces CRP and IL6, but does not affect other endocrine axes in healthy older adults. Horm Metab Res. 2008 Mar;40(3):199-205.

 

42. Walfisch S, Walfisch Y, Kirilov E, Linde N, Mnitentag H, Agbaria R, Sharoni Y, Levy U.  Tomato lycopene extract supplementation decreases insulin-like growth factor-I levels in colon cancer patients.  Eur J Cancer Prev. 2007 Aug;16(4):298-303.

 

Singer CF, Hudelist G, Schreiber M, Kubista E. Pharmacological modulation of IGF serum concentrations as a therapeutic approach to control the growth of malignant breast tumors. Drugs Today (Barc). 2003 Feb;39(2):115-25.

 

Lowe L, Hansen CM, Senaratne S, Colston KW. Mechanisms implicated in the growth regulatory effects of vitamin D compounds in breast cancer cells. Recent Results Cancer Res. 2003;164:99-110.

 

43. Pollack MN. Insulin, insulin-like growth factors, insulin resistance, and neoplasia. Am J Clin Nutr. 2007 Sep;86(3):s820-2.

 

Rotella CM, Monami M, Mannucci E. Metformin beyond diabetes: new life for an old drug. Curr Diabetes Rev. 2006 Aug;2(3):307-15.

 

Hede K. Doctors seek to prevent breast cancer recurrence by lowering insulin levels. J Natl Cancer Inst. 2008 Apr 16;100(8):530-2.

 

44. Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med. 2007 Jun 14;356(24):2457-71.

 

Anon. Important Safety Information for Avandia® (rosiglitazone maleate). Available at: http://www.avandia.com/avandia/avandia-safety-information.html.  Accessed July 12, 2008.

Anon. Important Safety Information.  Available at: http://www.actos.com/actos/safetyinfo.aspx. Accessed July 12, 2008.

Burgermeister E, Seger R. PPARgamma and MEK Interactions in Cancer. PPAR Res. 2008;2008:309469.

 

45. da Silva BB, Moita DS, Pires CG, Sousa-Junior EC, dos Santos AR, Lopes-Costa PV. Evaluation of insulin-like growth factor-I in postmenopausal women with breast cancer treated with raloxifene. Int Semin Surg Oncol. 2007 Jul 23;4:18.

 

Decensi A, Johansson H, Miceli R, Mariani L, Camerini T, Cavadini E, Di Mauro MG, Barreca A, Gonzaga AG, Diani S, Sandri MT, De Palo G, Formelli F. Long-term effects of fenretinide, a retinoic acid derivative, on the insulin-like growth factor system in women with early breast cancer. Cancer Epidemiol Biomarkers Prev. 2001 Oct;10(10):1047-53.

 

Guerrieri-Gonzaga A, Robertson C, Bonanni B, Serrano D, Cazzaniga M, Mora S, Gulisano M, Johansson H, Formelli F, Intra M, Latronico A, Franchi D, Pelosi G, Johnson K, Decensi A. Preliminary results on safety and activity of a randomized, double-blind, 2 x 2 trial of low-dose tamoxifen and fenretinide for breast cancer prevention in premenopausal women. J Clin Oncol. 2006 Jan 1;24(1):129-35.

 

46. Boyd DB.  Insulin and cancer.  Integrative Cancer Therapies 2003; 2(4): 315-29..

 

47. Crawford ED, Eisenberger MA, McLeod DG, et al.  A controlled trial of leuprolide with and  without flutamide in prostatic carcinoma.  N Engl J Med 1989; 321:419-24.

 

48. Xiang GD, Sun HL, Zhao LS, Hou J, Yue L, Xu L. The antioxidant alpha-lipoic acid improves endothelial dysfunction induced by acute hyperglycaemia during OGTT in impaired glucose tolerance. Clin Endocrinol (Oxf). 2008 May;68(5):716-23.

 

Kamenova P. Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid. Hormones (Athens). 2006 Oct-Dec;5(4):251-8.

 

Hipkiss AR. Brownson C. Bertani MF. Ruiz E. Ferro A.  Reaction of carnosine with aged proteins: another protective process?. Annals of the New York Academy of Sciences. 959:285-94, 2002

 

Nagai K, Suda T.  Realization of spontaneous healing function by carnosine.  Methods & Findings in Experimental & Clinical Pharmacology. 10(8):497-507, 1988

 

Hipkiss  AR.  Carnosine, a protective, anti-ageing peptide?  International Journal of Biochemistry & Cell Biology. 30(8):863-8, 1998

49. Singh D, Yi WS, Brasacchio RA, Muhs AG, Smudzin T, Williams JP, Messing E, Okunieff P.Is there a favorable subset of patients with prostate cancer who develop oligometastases?. Int J Radiat Oncol Biol Phys. 2004 Jan 1;58(1):3-10.